There just aren’t many comedies about cancer. How does one make a light-hearted film about such a brutal and devastating disease that nearly every person on the planet has been affected by in some way? Perhaps having a screenwriter such as Will Reiser, who is a cancer survivor, would be a good first step. A second step may be hiring talented and likable actors such as Joseph Gordon-Levitt and Seth Rogen who can balance comedy and still do the drama without getting overly sentimental.

Formally titled I’m With Cancer, 50/50 is that comedy and it looks damn good. Both actors are doing their usual thing – along with Bryce Dallas Howard, Anna Kendrick, and Anjelica Huston – and the movie looks like it may have found the way to successfully approach such a tragedy with the right touch of humor. If they market this right, between the universally understood subject material and the star power of these two popular actors, this could be a big hit when it is released on September 30.

What do you think of the trailer? Does it look to be a success or am I simply blinded by my man crush on JGL?